Skin biology & regeneration

The skin is a complex organ that serves as a physical barrier protecting organisms from dehydration, infection, and insults. It is comprised of multiple tissues and cell types that together regulate body temperature, form arrays of sensations, and construct an immune surveillance. During homeostasis, the skin structure and function is maintained by stem cell dependent and independent mechanisms. Furthermore, when the skin barrier is breached, a myriad of cell types, signaling pathways, and biological processes coordinate to re-establish skin integrity and function. We aim to unveil the molecular communications between the different tissues and cell types used to maintain skin integrity during homeostasis and wound repair.