The stem cell niche of the hair follicle is composed of multiple components that some are constantly rearranged as a result of the morphological changes imposed by the hair cycle. This constant rearrangement of the niche further entails additional level of regulation that maintains the functionality of the niche despite its structural redisposition during the hair cycle. The mature hair follicle throughout the hair cycle is largely composed of two compartments derived from embryonically-distinct origins; the follicular epidermis with its differentiated and undifferentiated epithelial cell-types collectively called keratinocytes, and the dermal papilla (DP), a compact group of mesenchymal cells at the base of the follicle that constitutes an important part of the stem cell niche and plays an important role in regulating different aspects of hair biology. Our research focuses on understanding the mechanisms by which the DP as a niche regulates stem cell and progenitor activity and thus orchestrates the hair cycle.